MARVELD3

Across TCGA patient cohorts, MARVELD3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARVELD3-associated genes across cancer lineages are MSH2, Annexin-1, and Caspase-8. Each is linked with MARVELD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARVELD3-to-partner and partner-to-MARVELD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by MARVELD3-low versus MARVELD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARVELD3→partner) and Y-score (partner→MARVELD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.217	-2.973	.019	.035	3	2
UCEC	Annexin-1 →	+0.475	+2.459	.025	.018	3	2
UCEC	Caspase-8 →	-0.286	-3.087	.004	<.001	3	2
UCEC	EGFR_pY1068 →	-0.279	-3.087	.005	<.001	3	1
UCEC	Ku80 →	+0.209	+1.920	.028	.009	3	1
UCEC	Notch1 →	+0.175	+1.598	.002	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MSH2 by MARVELD3 expression — UCEC

Explore this box plot interactively →