MARVELD3

Across TCGA cell cohorts, MARVELD3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible MARVELD3-associated genes across cancer lineages are SLC15A5, USP17L4, and HMGB4. Each is linked with MARVELD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARVELD3-to-partner and partner-to-MARVELD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC15A5 grouped by MARVELD3-low versus MARVELD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARVELD3→partner) and Y-score (partner→MARVELD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
CNS	USP17L4 →	+0.039	+4.643	<.001	.003	3	1
STOMACH	HMGB4 →	+0.017	+4.285	<.001	.007	3	1
STOMACH	DYNAP →	+0.106	+4.129	<.001	.007	3	1
STOMACH	OR13C5 →	+0.012	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SLC15A5 by MARVELD3 expression — LARGE_INTESTINE

Explore this box plot interactively →