MARS2

Across TCGA pan-cancer cohorts, MARS2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MARS2 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MARS2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MARS2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and UCEC are the cancer types where MARS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.502	.001	30	view →
LUAD	DFS	Tertile	III,IV	0.962	0.471	.031	6	view →
UCEC	DFS	Tertile	III,IV	1.000	0.510	.049	4	view →
CCRCC	DFS	Quartile	All	0.978	0.517	.036	2	view →
HNSC	DFS	Quartile	All	1.000	0.924	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MARS2–LSCC (OS)

Open the LSCC breakdown →