MARS1

Across TCGA pan-cancer cohorts, MARS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MARS1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MARS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MARS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where MARS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.456	0.908	.001	33	view →
CCRCC	OS	Median	All	0.656	1.000	.006	16	view →
HNSC	DFS	Median	All	0.837	0.718	.022	9	view →
LSCC	OS	Median	II,III,IV	1.000	0.889	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MARS1–LUAD (OS)

Open the LUAD breakdown →