MARK4

Across TCGA patient cohorts, MARK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,837 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MARK4-associated proteins across cancer lineages are TRIM28, PPP5C, and DBN1. Each is linked with MARK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both MARK4-to-partner and partner-to-MARK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MARK4 versus TRIM28 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK4→partner) and Y-score (partner→MARK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM28 →	+0.441	+0.406	<.001	<.001	3	5
GBM	PPP5C →	+0.365	+0.504	<.001	<.001	3	5
UCEC	DBN1 →	+0.421	+0.396	.001	.004	3	5
OV	FLT1 →	+0.390	+0.505	.002	<.001	3	5
BRCA	ARHGAP35 →	+0.364	+0.418	.001	.001	3	4
LUAD	CAST →	-0.395	-0.403	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,837 associations by consensus.

MARK4 vs TRIM28 — GBM

Explore this scatter interactively →