MARK4

Across TCGA cell cohorts, MARK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,169 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARK4-associated GO terms across cancer lineages are Regulation of protein localization to centrosome, Negative regulation of calcium ion export across plasma membrane, and Regulation of organelle assembly. Each is linked with MARK4 in more than 16 cancer types. Because this analysis shows association rather than direction, both MARK4-to-partner and partner-to-MARK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to centrosome grouped by MARK4-low versus MARK4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK4→partner) and Y-score (partner→MARK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of protein localization to centrosome →	+0.130	+1.511	<.001	<.001	3	17
STOMACH	Negative regulation of calcium ion export across plasma membrane →	+0.089	+1.343	.001	<.001	3	17
LUNG_NSCLC_LUSC	Regulation of organelle assembly →	+0.062	+1.010	.006	.002	3	16
STOMACH	Negative regulation of smoothened signaling pathway →	+0.101	+1.346	<.001	.002	3	15
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.114	+1.013	<.001	.003	3	14
STOMACH	Response to starvation →	+0.067	+1.417	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,169 associations by consensus.

Regulation of protein localization to centrosome by MARK4 expression — STOMACH

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