MARK4

Across TCGA cell cohorts, MARK4 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARK4-associated genes across cancer lineages are TEX43, MS4A2, and MRGPRX1. Each is linked with MARK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARK4-to-partner and partner-to-MARK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by MARK4-low versus MARK4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK4→partner) and Y-score (partner→MARK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TEX43 →	+0.070	+3.969	<.001	.009	3	2
BONE	MS4A2 →	+0.030	+5.169	<.001	.004	3	1
BONE	MRGPRX1 →	+0.033	+5.169	<.001	.004	3	1
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
LUNG_SCLC	GPR33 →	+0.032	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

TEX43 by MARK4 expression — BLOOD_Leukemia

Explore this box plot interactively →