MARK3

Across TCGA patient cohorts, MARK3 mutation is significantly associated with the RNA expression of many other genes, with 2,494 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARK3-associated genes across cancer lineages are DOC2B, TAF9, and CCL4. Each is linked with MARK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARK3-to-partner and partner-to-MARK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOC2B grouped by MARK3-low versus MARK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK3→partner) and Y-score (partner→MARK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOC2B →	-0.976	-2.641	<.001	<.001	3	2
UCEC	TAF9 →	+0.583	+3.269	<.001	<.001	3	2
UCEC	CCL4 →	+0.732	+2.072	<.001	<.001	3	2
UCEC	H3C7 →	+0.467	+1.609	.009	.005	3	2
UCEC	GEMIN4 →	+0.349	+1.869	.007	.004	3	2
UCEC	TIGD2 →	+0.445	+2.524	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,494 associations by consensus.

DOC2B by MARK3 expression — UCEC

Explore this box plot interactively →