MARK3

Across TCGA cell cohorts, MARK3 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARK3-associated genes across cancer lineages are PRR23B, SLC10A2, and FTMT. Each is linked with MARK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARK3-to-partner and partner-to-MARK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23B grouped by MARK3-low versus MARK3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK3→partner) and Y-score (partner→MARK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRR23B →	+0.010	+4.285	<.001	.007	3	2
SOFT_TISSUE	SLC10A2 →	+0.286	+4.635	<.001	.003	3	1
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
SOFT_TISSUE	ZNF735 →	+0.135	+4.369	<.001	.008	3	1
URINARY_TRACT	LCE2B →	+0.253	+5.087	<.001	.004	3	1
BLOOD_Leukemia	CRYAA →	+0.049	+4.705	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PRR23B by MARK3 expression — STOMACH

Explore this box plot interactively →