MARK2

Across TCGA patient cohorts, MARK2 mutation is significantly associated with the RNA expression of many other genes, with 1,937 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARK2-associated genes across cancer lineages are CENPU, MBD2, and RNF138. Each is linked with MARK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MARK2-to-partner and partner-to-MARK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by MARK2-low versus MARK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK2→partner) and Y-score (partner→MARK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.502	+2.321	.009	.006	3	4
UCEC	MBD2 →	+0.378	+1.981	.003	<.001	3	3
UCEC	RNF138 →	+0.504	+2.016	.003	.005	3	3
UCEC	RMC1 →	+0.293	+2.024	.005	.005	3	3
UCEC	MBD1 →	+0.301	+2.008	.006	.005	3	3
UCEC	C18orf25 →	+0.501	+2.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,937 associations by consensus.

CENPU by MARK2 expression — UCEC

Explore this box plot interactively →