MARK2

Across TCGA patient cohorts, MARK2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARK2-associated genes across cancer lineages are Caspase-7-cleavedD198, Lck, and Shc_pY317. Each is linked with MARK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MARK2-to-partner and partner-to-MARK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MARK2-low versus MARK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK2→partner) and Y-score (partner→MARK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.604	.006	.041	3	3
UCEC	Lck →	+0.228	+1.765	.002	.014	3	2
UCEC	Shc_pY317 →	-0.179	-2.169	.001	.003	3	2
UCEC	C-Raf_pS338 →	-0.077	-1.765	.011	.014	3	2
SKCM	ERK2 →	+0.287	+3.000	.012	.035	3	2
UCEC	A-Raf_pS299 →	-0.139	-2.169	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by MARK2 expression — UCEC

Explore this box plot interactively →