MARK2

Across TCGA cell cohorts, MARK2 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARK2-associated genes across cancer lineages are GUCA2A, LECT2, and SLC38A8. Each is linked with MARK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARK2-to-partner and partner-to-MARK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by MARK2-low versus MARK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK2→partner) and Y-score (partner→MARK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	2
BLOOD_Lymphoma	LECT2 →	+0.891	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	SLC38A8 →	+0.054	+4.191	.009	.007	3	1
BREAST	BMP15 →	+0.016	+5.781	<.001	.001	3	1
LARGE_INTESTINE	KRT85 →	+0.331	+2.560	<.001	.009	3	1
LARGE_INTESTINE	SLC9A5 →	+0.740	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

GUCA2A by MARK2 expression — BLOOD_Leukemia

Explore this box plot interactively →