MARK1

Across TCGA patient cohorts, MARK1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARK1-associated genes across cancer lineages are Cyclin-B1, eIF4E, and Ku80. Each is linked with MARK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MARK1-to-partner and partner-to-MARK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MARK1-low versus MARK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK1→partner) and Y-score (partner→MARK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.543	+3.807	.001	<.001	3	4
COAD	eIF4E →	+0.261	+3.012	.001	.018	3	2
UCEC	Ku80 →	+0.148	+1.138	.037	.022	3	2
UCEC	p62 Lck ligand →	+0.350	+2.257	<.001	<.001	3	2
UCEC	PCNA →	+0.204	+1.999	.001	.008	3	2
UCEC	STAT3_pY705 →	-0.415	-2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Cyclin-B1 by MARK1 expression — UCEC

Explore this box plot interactively →