MARK1

Across TCGA cell cohorts, MARK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,144 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MARK1-associated GO terms across cancer lineages are Negative regulation of RNA catabolic process, Regulation of mRNA catabolic process, and Spliceosomal conformational changes to generate catalytic conformation. Each is linked with MARK1 in more than 10 cancer types. Because this analysis shows association rather than direction, both MARK1-to-partner and partner-to-MARK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA catabolic process grouped by MARK1-low versus MARK1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK1→partner) and Y-score (partner→MARK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of RNA catabolic process →	+0.077	+2.029	.001	<.001	3	11
LIVER	Regulation of mRNA catabolic process →	+0.061	+1.515	<.001	<.001	3	11
STOMACH	Spliceosomal conformational changes to generate catalytic conformation →	+0.117	+1.762	<.001	<.001	3	10
LIVER	Regulation of RNA stability →	+0.063	+1.807	.001	<.001	3	10
LIVER	Regulation of mRNA stability →	+0.064	+1.366	<.001	.003	3	10
OVARY	Calcium ion transmembrane transport →	-0.054	-1.309	.004	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,144 associations by consensus.

Negative regulation of RNA catabolic process by MARK1 expression — URINARY_TRACT

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