MARK1

Across TCGA cell cohorts, MARK1 mutation is significantly associated with the RNA expression of many other genes, with 454 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARK1-associated genes across cancer lineages are BBS7, PPP1R42, and CRYGD. Each is linked with MARK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARK1-to-partner and partner-to-MARK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBS7 grouped by MARK1-low versus MARK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK1→partner) and Y-score (partner→MARK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBS7 →	+0.727	+3.364	<.001	.002	3	2
LARGE_INTESTINE	PPP1R42 →	+0.068	+2.681	.003	.002	3	2
SKIN	CRYGD →	+0.707	+5.415	<.001	.004	3	1
LUNG_SCLC	GAPDHS →	+0.067	+3.628	<.001	.009	3	1
LUNG_SCLC	IQCF1 →	+0.137	+4.220	<.001	<.001	3	1
LUNG_SCLC	OR4A16 →	+0.015	+3.232	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 454 associations by consensus.

BBS7 by MARK1 expression — LARGE_INTESTINE

Explore this box plot interactively →