MARK1

Across TCGA cell cohorts, MARK1 mutation is significantly associated with the mutation status of many other genes, with 5,801 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARK1-associated genes across cancer lineages are SLX4, CDH20, and LTBP1. Each is linked with MARK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MARK1-to-partner and partner-to-MARK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLX4 grouped by MARK1-low versus MARK1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK1→partner) and Y-score (partner→MARK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLX4 →	+2.681	+2.906	.005	.005	1	5
BLOOD_Leukemia	CDH20 →	+3.313	+3.430	.005	.005	1	5
BLOOD_Leukemia	LTBP1 →	+3.313	+3.430	.005	.005	1	5
LARGE_INTESTINE	LAMA1 →	+1.941	+3.459	<.001	<.001	1	5
SOFT_TISSUE	COL7A1 →	+4.502	+5.066	.007	.007	1	5
BLOOD_Leukemia	PLCL1 →	+3.635	+3.635	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,801 associations by consensus.

SLX4 by MARK1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →