MARF1

Across TCGA pan-cancer cohorts, MARF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MARF1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MARF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MARF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where MARF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.966	0.725	.001	44	view →
UCEC	OS	Quartile	All	1.000	0.810	.007	36	view →
PDAC	OS	Median	III,IV	0.545	0.942	<.001	32	view →
CCRCC	DFS	Median	IV	0.131	0.861	.006	12	view →
LSCC	DFS	Quartile	II,III,IV	0.229	1.000	.038	3	view →
GBM	OS	Median	All	0.439	0.629	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MARF1–HNSC (OS)

Open the HNSC breakdown →