MARF1

Across TCGA patient cohorts, MARF1 mutation is significantly associated with the RNA expression of many other genes, with 4,734 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARF1-associated genes across cancer lineages are PBK, RAD51, and ORC1. Each is linked with MARF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MARF1-to-partner and partner-to-MARF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by MARF1-low versus MARF1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARF1→partner) and Y-score (partner→MARF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PBK →	+1.004	+3.182	.002	.009	3	5
UCEC	RAD51 →	+0.708	+2.105	<.001	<.001	3	5
UCEC	ORC1 →	+0.525	+1.721	<.001	<.001	3	5
COAD	SCO1 →	+0.498	+3.916	<.001	<.001	3	4
UCEC	AURKB →	+0.566	+2.949	<.001	<.001	3	4
COAD	GEMIN4 →	+0.601	+3.049	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,734 associations by consensus.

PBK by MARF1 expression — STAD

Explore this box plot interactively →