MARCO

Across TCGA patient cohorts, MARCO protein abundance is significantly associated with the RNA expression of many other genes, with 6,111 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MARCO-associated genes across cancer lineages are HMOX1, RIN3, and CD33. Each is linked with MARCO in more than 3 cancer types. Because this analysis shows association rather than direction, both MARCO-to-partner and partner-to-MARCO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MARCO versus HMOX1 in LSCC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCO→partner) and Y-score (partner→MARCO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HMOX1 →	+0.915	+0.783	<.001	<.001	3	4
OV	RIN3 →	+1.101	+0.487	<.001	.001	3	4
OV	CD33 →	+0.546	+0.427	.004	.008	3	4
OV	LILRB5 →	+0.711	+0.638	<.001	<.001	3	4
OV	CD4 →	+1.170	+0.468	<.001	.003	3	4
PDAC	MCEMP1 →	+1.171	+1.168	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,111 associations by consensus.

MARCO vs HMOX1 — LSCC

Explore this scatter interactively →