MARCO

Across TCGA patient cohorts, MARCO mutation is significantly associated with the RNA expression of many other genes, with 3,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCO-associated genes across cancer lineages are SKA2, CENPN, and DTYMK. Each is linked with MARCO in more than 4 cancer types. Because this analysis shows association rather than direction, both MARCO-to-partner and partner-to-MARCO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA2 grouped by MARCO-low versus MARCO-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCO→partner) and Y-score (partner→MARCO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SKA2 →	+0.472	+3.379	.003	.004	3	5
UCEC	CENPN →	+0.487	+2.343	.003	.003	3	4
SKCM	DTYMK →	+0.289	+1.251	.002	<.001	3	4
SKCM	FEN1 →	+0.279	+2.175	.005	<.001	3	4
LUSC	TMEM126A →	+0.376	+3.538	.003	.002	3	4
UCEC	TMX2 →	+0.387	+2.031	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,031 associations by consensus.

SKA2 by MARCO expression — LUSC

Explore this box plot interactively →