MARCO

Across TCGA patient cohorts, MARCO mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCO-associated genes across cancer lineages are MEK1, JAB1, and Rb_pS807_S811. Each is linked with MARCO in more than 2 cancer types. Because this analysis shows association rather than direction, both MARCO-to-partner and partner-to-MARCO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MARCO-low versus MARCO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCO→partner) and Y-score (partner→MARCO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.337	+3.000	.007	<.001	3	3
SKCM	JAB1 →	+0.160	+2.459	.024	.014	3	2
SKCM	Rb_pS807_S811 →	+0.244	+0.954	.034	.026	3	2
UCEC	PCNA →	+0.173	+1.678	.020	.021	3	2
UCEC	PDCD4 →	-0.522	-2.405	.001	.003	3	2
UCEC	TIGAR →	+0.152	+1.763	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MEK1 by MARCO expression — UCEC

Explore this box plot interactively →