MARCO

Across TCGA cell cohorts, MARCO RNA expression is significantly associated with the go_rna of many other GO terms, with 1,799 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARCO-associated GO terms across cancer lineages are Motile cilium assembly, Acute-phase response, and Positive regulation of cytokine-mediated signaling pathway. Each is linked with MARCO in more than 6 cancer types. Because this analysis shows association rather than direction, both MARCO-to-partner and partner-to-MARCO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Motile cilium assembly grouped by MARCO-low versus MARCO-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCO→partner) and Y-score (partner→MARCO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Motile cilium assembly →	-0.037	-0.088	.001	.001	3	6
BREAST	Acute-phase response →	+0.135	+0.574	.001	.003	3	6
LUNG_NSCLC_LUSC	Positive regulation of cytokine-mediated signaling pathway →	+0.090	+0.274	.009	.001	3	6
STOMACH	Spermatid differentiation →	-0.049	-0.842	<.001	.006	3	6
STOMACH	Regulation of mitochondrial membrane potential →	+0.092	+0.593	<.001	.007	3	6
UPPER_AERODIGESTIVE_TRACT	Sperm flagellum assembly →	-0.036	-0.842	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,799 associations by consensus.

Motile cilium assembly by MARCO expression — KIDNEY

Explore this box plot interactively →