MARCKS

Across TCGA pan-cancer cohorts, MARCKS mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MARCKS’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MARCKS mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MARCKS is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where MARCKS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MARCKS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	+0.831	<.001	12	view →
HNSC	Male	II,III,IV	+0.623	<.001	12	view →
COAD	Female	III,IV	−0.840	<.001	11	view →
LSCC	Female	All	+0.452	<.001	8	view →
PDAC	All	All	−0.223	.003	6	view →
LUAD	Female	All	−0.201	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MARCKS–CCRCC

Open the CCRCC breakdown →