MARCHF9

Across TCGA patient cohorts, MARCHF9 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF9-associated genes across cancer lineages are PPP1R2P5, MBD3L3, and MIR8071-1. Each is linked with MARCHF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF9-to-partner and partner-to-MARCHF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R2P5 grouped by MARCHF9-low versus MARCHF9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF9→partner) and Y-score (partner→MARCHF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP1R2P5 →	+0.038	+4.624	<.001	.005	3	2
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
UCEC	MIR8071-1 →	+1.541	+3.022	<.001	.004	3	1
SKCM	CICP15 →	+0.015	+4.292	<.001	.001	3	1
SKCM	GPR149 →	+0.053	+4.180	<.001	.001	3	1
SKCM	RN7SKP184 →	+0.065	+4.328	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

PPP1R2P5 by MARCHF9 expression — SKCM

Explore this box plot interactively →