MARCHF9

Across TCGA cell cohorts, MARCHF9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,313 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARCHF9-associated GO terms across cancer lineages are Positive regulation of toll-like receptor signaling pathway, Establishment of epithelial cell apical/basal polarity, and Plasma lipoprotein particle clearance. Each is linked with MARCHF9 in more than 7 cancer types. Because this analysis shows association rather than direction, both MARCHF9-to-partner and partner-to-MARCHF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of toll-like receptor signaling pathway grouped by MARCHF9-low versus MARCHF9-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF9→partner) and Y-score (partner→MARCHF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of toll-like receptor signaling pathway →	+0.100	+1.056	<.001	<.001	2	8
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	-0.187	-1.159	<.001	<.001	3	7
BREAST	Plasma lipoprotein particle clearance →	-0.144	-1.174	<.001	<.001	3	7
LUNG_SCLC	Pyrimidine nucleoside diphosphate biosynthetic process →	-0.127	-1.179	<.001	<.001	3	7
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.087	+1.213	.001	.001	3	7
PANCREAS	Apoptotic signaling pathway →	+0.041	+0.808	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,313 associations by consensus.

Positive regulation of toll-like receptor signaling pathway by MARCHF9 expression — BLOOD_Leukemia

Explore this box plot interactively →