MARCHF8

Across TCGA patient cohorts, MARCHF8 mutation is significantly associated with the RNA expression of many other genes, with 2,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF8-associated genes across cancer lineages are FAM74A6, RNU6-154P, and RNA5SP231. Each is linked with MARCHF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF8-to-partner and partner-to-MARCHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM74A6 grouped by MARCHF8-low versus MARCHF8-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF8→partner) and Y-score (partner→MARCHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM74A6 →	+0.025	+6.324	<.001	.001	3	2
KIRC	RNU6-154P →	+0.361	+6.184	<.001	.001	3	2
KIRC	RNA5SP231 →	+0.224	+5.509	.006	.004	3	2
KIRC	OR4A12P →	+0.046	+5.509	<.001	.004	3	2
BRCA	RNU6-24P →	+0.349	+5.148	.001	.008	3	2
COAD	REG1CP →	+0.623	+4.007	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,867 associations by consensus.

FAM74A6 by MARCHF8 expression — BRCA

Explore this box plot interactively →