MARCHF8

Across TCGA patient cohorts, MARCHF8 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF8-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Notch1. Each is linked with MARCHF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF8-to-partner and partner-to-MARCHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MARCHF8-low versus MARCHF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF8→partner) and Y-score (partner→MARCHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.274	-2.222	.010	.011	3	2
UCEC	MEK1 →	+0.508	+3.807	.001	<.001	3	2
UCEC	Notch1 →	+0.128	+2.222	.032	.011	3	2
UCEC	PDCD4 →	-0.409	-2.222	.040	.011	3	2
UCEC	C-Raf →	+0.165	+1.700	.006	.044	3	2
UCEC	eIF4E →	+0.206	+3.183	.021	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by MARCHF8 expression — UCEC

Explore this box plot interactively →