MARCHF8

Across TCGA cell cohorts, MARCHF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,009 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARCHF8-associated GO terms across cancer lineages are Protein localization to endosome, Macroautophagy, and Endosomal transport. Each is linked with MARCHF8 in more than 14 cancer types. Because this analysis shows association rather than direction, both MARCHF8-to-partner and partner-to-MARCHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to endosome grouped by MARCHF8-low versus MARCHF8-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF8→partner) and Y-score (partner→MARCHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein localization to endosome →	+0.131	+0.968	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Macroautophagy →	+0.066	+1.029	<.001	<.001	3	15
LUNG_SCLC	Endosomal transport →	+0.056	+1.123	<.001	.002	3	14
LUNG_NSCLC_LUSC	Regulation of vacuole organization →	+0.097	+1.154	<.001	.004	3	14
LUNG_NSCLC_LUSC	Process utilizing autophagic mechanism →	+0.068	+0.988	.001	.001	3	14
LUNG_NSCLC_LUSC	Autophagy →	+0.068	+0.988	.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,009 associations by consensus.

Protein localization to endosome by MARCHF8 expression — OESOPHAGUS

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