MARCHF8

Across TCGA cell cohorts, MARCHF8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARCHF8-associated genes across cancer lineages are OR10W1, CARTPT, and RTP2. Each is linked with MARCHF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF8-to-partner and partner-to-MARCHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by MARCHF8-low versus MARCHF8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF8→partner) and Y-score (partner→MARCHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1
BLOOD_Leukemia	CARTPT →	+0.039	+5.539	<.001	.003	3	1
BLOOD_Leukemia	RTP2 →	+0.019	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10W1 by MARCHF8 expression — LARGE_INTESTINE

Explore this box plot interactively →