MARCHF7

Across TCGA patient cohorts, MARCHF7 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF7-associated genes across cancer lineages are eIF4E, Annexin-1, and ATM. Each is linked with MARCHF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF7-to-partner and partner-to-MARCHF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MARCHF7-low versus MARCHF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF7→partner) and Y-score (partner→MARCHF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.225	+2.643	.001	<.001	3	2
UCEC	Annexin-1 →	+0.478	+2.584	.005	.010	3	2
UCEC	ATM →	-0.487	-2.209	.001	.009	3	2
UCEC	4E-BP1 →	+0.418	+3.999	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.853	+2.263	<.001	<.001	3	2
UCEC	53BP1 →	+0.241	+2.115	.032	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

eIF4E by MARCHF7 expression — UCEC

Explore this box plot interactively →