MARCHF7

Across TCGA cell cohorts, MARCHF7 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARCHF7-associated genes across cancer lineages are RFPL3, NAT8B, and ITGAD. Each is linked with MARCHF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF7-to-partner and partner-to-MARCHF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by MARCHF7-low versus MARCHF7-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF7→partner) and Y-score (partner→MARCHF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RFPL3 →	+0.099	+3.491	<.001	.004	3	1
BLOOD_Myeloma	NAT8B →	+0.150	+3.000	.002	.007	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	MAGEB18 →	+0.045	+2.994	<.001	.006	3	1
LARGE_INTESTINE	ADIPOQ →	+0.009	+3.217	<.001	.006	3	1
LARGE_INTESTINE	NPY2R →	+0.003	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RFPL3 by MARCHF7 expression — BLOOD_Myeloma

Explore this box plot interactively →