MARCHF6

Across TCGA patient cohorts, MARCHF6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF6-associated genes across cancer lineages are TFRC, ATM, and NF2. Each is linked with MARCHF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MARCHF6-to-partner and partner-to-MARCHF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by MARCHF6-low versus MARCHF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF6→partner) and Y-score (partner→MARCHF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.447	+1.392	.010	.019	3	3
UCEC	ATM →	-0.753	-2.643	<.001	<.001	3	3
COAD	NF2 →	+0.257	+2.815	.016	.036	2	2
COAD	ASNS →	+0.618	+2.815	.004	.036	1	3
COAD	Cyclin-E1 →	+0.293	+2.815	.033	.036	3	1
UCEC	eIF4E →	+0.224	+2.263	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

TFRC by MARCHF6 expression — UCEC

Explore this box plot interactively →