Across TCGA patient cohorts, MARCHF5 protein abundance is significantly associated with the RNA expression of many other genes, with 11,068 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MARCHF5-associated genes across cancer lineages are ITGB7, TRAV8-3, and ICAM3. Each is linked with MARCHF5 in more than 4 cancer types. Because this analysis shows association rather than direction, both MARCHF5-to-partner and partner-to-MARCHF5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF5→partner) and Y-score (partner→MARCHF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGB7 →	-0.640	-0.377	<.001	.008	3	4
UCEC	TRAV8-3 →	-0.896	-0.398	.001	.001	3	4
BRCA	ICAM3 →	-0.551	-0.385	<.001	.009	3	4
OV	ZNF407 →	-0.575	-0.207	.001	.008	3	4
OV	DPYSL2 →	-1.228	-0.399	<.001	<.001	3	4
LSCC	ITGAX →	-0.746	-0.245	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,068 associations by consensus.

Exploration

MARCHF5 survival (RNA) · tumor vs normal (RNA) · all MARCHF5 data types