Across TCGA patient cohorts, MARCHF5 mutation is significantly associated with the RNA expression of many other genes, with 3,795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF5-associated genes across cancer lineages are MIR6853, TAF15, and HNRNPA3P9. Each is linked with MARCHF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF5-to-partner and partner-to-MARCHF5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF5→partner) and Y-score (partner→MARCHF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
UCEC	TAF15 →	+0.347	+1.942	.008	.002	3	1
UCEC	HNRNPA3P9 →	+0.219	+1.684	.008	.003	3	1
UCEC	RPL23AP90 →	+0.224	+1.802	.004	<.001	3	1
UCEC	CCL5 →	+0.831	+3.103	.005	<.001	3	1
UCEC	LINC02427 →	-0.208	-1.895	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,795 associations by consensus.

Exploration

MARCHF5 survival (RNA) · tumor vs normal (RNA) · all MARCHF5 data types