Across TCGA patient cohorts, MARCHF5 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF5-associated genes across cancer lineages are eEF2, eIF4G, and A-Raf_pS299. Each is linked with MARCHF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF5-to-partner and partner-to-MARCHF5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF5→partner) and Y-score (partner→MARCHF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.345	+2.459	.005	.018	3	1
UCEC	eIF4G →	+0.274	+2.070	.010	.001	3	1
UCEC	A-Raf_pS299 →	-0.122	-1.584	.003	.034	3	1
UCEC	ERK2 →	+0.138	+1.440	.039	.024	3	1
UCEC	FOXO3a_pS318_S321 →	-0.129	-1.575	.002	.017	3	1
UCEC	GAPDH →	+0.395	+2.584	.033	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

MARCHF5 survival (RNA) · tumor vs normal (RNA) · all MARCHF5 data types