MARCHF4

Across TCGA patient cohorts, MARCHF4 mutation is significantly associated with the RNA expression of many other genes, with 1,370 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF4-associated genes across cancer lineages are CDCA2, CHEK1, and PITPNC1. Each is linked with MARCHF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MARCHF4-to-partner and partner-to-MARCHF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by MARCHF4-low versus MARCHF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF4→partner) and Y-score (partner→MARCHF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.739	+3.716	.004	<.001	3	3
UCEC	CHEK1 →	+0.695	+3.724	.001	<.001	3	2
UCEC	PITPNC1 →	+0.742	+2.906	<.001	.002	3	2
UCEC	MRPL39 →	+0.488	+2.917	.001	.001	3	2
UCEC	EME1 →	+0.640	+2.917	.002	.001	3	2
UCEC	LSM12 →	+0.659	+3.210	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,370 associations by consensus.

CDCA2 by MARCHF4 expression — UCEC

Explore this box plot interactively →