MARCHF4

Across TCGA patient cohorts, MARCHF4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF4-associated genes across cancer lineages are Cyclin-E2, 14-3-3_beta, and eEF2. Each is linked with MARCHF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF4-to-partner and partner-to-MARCHF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by MARCHF4-low versus MARCHF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF4→partner) and Y-score (partner→MARCHF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.202	+3.469	.006	.002	3	2
UCEC	14-3-3_beta →	-0.127	-3.295	.003	.009	3	1
UCEC	eEF2 →	+0.456	+2.115	.003	.019	2	2
UCEC	A-Raf_pS299 →	-0.182	-3.321	<.001	.010	3	1
UCEC	FoxM1 →	+0.298	+2.115	.008	.019	3	1
UCEC	GATA6 →	-0.154	-2.321	.027	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Cyclin-E2 by MARCHF4 expression — UCEC

Explore this box plot interactively →