MARCHF4

Across TCGA cell cohorts, MARCHF4 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARCHF4-associated genes across cancer lineages are ZSCAN1, FOXR2, and TBL1Y. Each is linked with MARCHF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF4-to-partner and partner-to-MARCHF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN1 grouped by MARCHF4-low versus MARCHF4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF4→partner) and Y-score (partner→MARCHF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	FOXR2 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
LUNG_SCLC	CLEC4E →	+0.068	+3.736	<.001	.007	3	1
LUNG_SCLC	ACSM2A →	+0.022	+3.523	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR11H1 →	+0.016	+3.786	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ZSCAN1 by MARCHF4 expression — PANCREAS

Explore this box plot interactively →