MARCHF3

Across TCGA patient cohorts, MARCHF3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF3-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Notch1. Each is linked with MARCHF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF3-to-partner and partner-to-MARCHF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MARCHF3-low versus MARCHF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF3→partner) and Y-score (partner→MARCHF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.282	-3.169	.012	.018	3	1
UCEC	JNK2 →	+0.304	+3.179	<.001	.010	3	1
UCEC	Notch1 →	+0.157	+2.331	.013	.019	3	1
UCEC	Annexin-1 →	+0.576	+2.341	.015	.019	3	1
UCEC	SETD2 →	-0.200	-2.000	.042	.032	3	1
UCEC	Shc_pY317 →	-0.266	-3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by MARCHF3 expression — UCEC

Explore this box plot interactively →