MARCHF3

Across TCGA cell cohorts, MARCHF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,313 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MARCHF3-associated GO terms across cancer lineages are Regulation of angiotensin-activated signaling pathway, Nuclear membrane disassembly, and Response to oxygen levels. Each is linked with MARCHF3 in more than 8 cancer types. Because this analysis shows association rather than direction, both MARCHF3-to-partner and partner-to-MARCHF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of angiotensin-activated signaling pathway grouped by MARCHF3-low versus MARCHF3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF3→partner) and Y-score (partner→MARCHF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of angiotensin-activated signaling pathway →	+0.161	+1.006	.005	.008	3	9
OVARY	Nuclear membrane disassembly →	+0.122	+1.437	.006	.001	3	9
SKIN	Response to oxygen levels →	+0.045	+1.170	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.064	+1.204	.002	<.001	3	8
BONE	Establishment of protein localization to membrane →	+0.090	+1.574	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Vacuolar transport →	+0.048	+1.092	.006	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,313 associations by consensus.

Regulation of angiotensin-activated signaling pathway by MARCHF3 expression — BONE

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