MARCHF3

Across TCGA cell cohorts, MARCHF3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARCHF3-associated genes across cancer lineages are CFHR2, JAKMIP1, and OR4F4. Each is linked with MARCHF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF3-to-partner and partner-to-MARCHF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by MARCHF3-low versus MARCHF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF3→partner) and Y-score (partner→MARCHF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	2
LARGE_INTESTINE	JAKMIP1 →	+0.246	+3.339	<.001	.007	3	1
LARGE_INTESTINE	OR4F4 →	+0.011	+3.103	.006	.004	3	1
BLOOD_Leukemia	PRKAG3 →	+0.035	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MMP20 →	+0.048	+3.705	<.001	.007	3	1
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CFHR2 by MARCHF3 expression — LARGE_INTESTINE

Explore this box plot interactively →