MARCHF2

Across TCGA patient cohorts, MARCHF2 mutation is significantly associated with the RNA expression of many other genes, with 819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF2-associated genes across cancer lineages are BUB3, ZCCHC4, and TET3. Each is linked with MARCHF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF2-to-partner and partner-to-MARCHF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by MARCHF2-low versus MARCHF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF2→partner) and Y-score (partner→MARCHF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.515	+3.459	.007	.005	3	2
UCEC	ZCCHC4 →	+0.467	+3.337	.003	.005	3	2
UCEC	TET3 →	+0.620	+3.202	.009	.009	3	2
UCEC	RNA5SP418 →	+1.190	+2.377	<.001	.008	3	2
UCEC	ACBD5 →	+0.916	+3.475	<.001	.002	3	2
UCEC	MDC1 →	+0.754	+3.212	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 819 associations by consensus.

BUB3 by MARCHF2 expression — UCEC

Explore this box plot interactively →