MARCHF2

Across TCGA patient cohorts, MARCHF2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF2-associated genes across cancer lineages are Heregulin, p70-S6K_pT389, and ATM. Each is linked with MARCHF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF2-to-partner and partner-to-MARCHF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by MARCHF2-low versus MARCHF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF2→partner) and Y-score (partner→MARCHF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.168	-3.000	.013	.036	3	1
UCEC	p70-S6K_pT389 →	-0.243	-3.169	.020	.020	3	1
UCEC	ATM →	-0.561	-3.169	.024	.020	3	1
UCEC	Di-Ras3 →	-0.247	-3.169	.002	.020	3	1
UCEC	Caspase-8 →	-0.354	-3.000	.010	.036	2	1
UCEC	4E-BP1 →	+0.551	+3.029	<.001	.018	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Heregulin by MARCHF2 expression — UCEC

Explore this box plot interactively →