MARCHF2

Across TCGA cell cohorts, MARCHF2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARCHF2-associated genes across cancer lineages are SGCZ, PRR20C, and PAX1. Each is linked with MARCHF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF2-to-partner and partner-to-MARCHF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGCZ grouped by MARCHF2-low versus MARCHF2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF2→partner) and Y-score (partner→MARCHF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SGCZ →	+0.401	+4.199	.003	.007	3	1
BREAST	PRR20C →	+0.078	+4.199	<.001	.007	3	1
BLOOD_Leukemia	PAX1 →	+0.042	+4.060	<.001	.003	3	1
BLOOD_Leukemia	BTBD16 →	+0.071	+3.959	.001	.005	3	1
BLOOD_Leukemia	CYP39A1 →	+0.152	+3.769	<.001	.008	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+4.037	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SGCZ by MARCHF2 expression — BREAST

Explore this box plot interactively →