MARCHF10

Across TCGA patient cohorts, MARCHF10 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF10-associated genes across cancer lineages are Caspase-7-cleavedD198, STAT3_pY705, and GAPDH. Each is linked with MARCHF10 in more than 2 cancer types. Because this analysis shows association rather than direction, both MARCHF10-to-partner and partner-to-MARCHF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MARCHF10-low versus MARCHF10-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF10→partner) and Y-score (partner→MARCHF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Caspase-7-cleavedD198 →	+1.193	+2.816	<.001	.036	3	3
UCEC	STAT3_pY705 →	-0.371	-1.893	<.001	<.001	3	3
SKCM	GAPDH →	+0.467	+1.765	.013	.012	3	2
SKCM	MYH11 →	-0.703	-1.874	.011	.049	3	2
UCEC	TFRC →	+0.419	+1.201	.011	.028	3	2
UCEC	XBP1 →	-0.176	-2.308	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by MARCHF10 expression — LUSC

Explore this box plot interactively →