MARCHF10

Across TCGA cell cohorts, MARCHF10 mutation is significantly associated with the mutation status of many other genes, with 3,106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARCHF10-associated genes across cancer lineages are AKT1, EIF5B, and GRK2. Each is linked with MARCHF10 in more than 3 cancer types. Because this analysis shows association rather than direction, both MARCHF10-to-partner and partner-to-MARCHF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKT1 grouped by MARCHF10-low versus MARCHF10-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF10→partner) and Y-score (partner→MARCHF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	AKT1 →	+5.392	+5.392	.004	.004	1	4
LARGE_INTESTINE	EIF5B →	+1.669	+2.070	.007	.007	1	4
BLOOD_Lymphoma	GRK2 →	+4.969	+4.014	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	OR5D18 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	RNF220 →	+5.392	+5.392	.004	.004	1	3
LARGE_INTESTINE	LONRF3 →	+3.321	+2.459	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,106 associations by consensus.

AKT1 by MARCHF10 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →