MARCHF1

Across TCGA patient cohorts, MARCHF1 mutation is significantly associated with the RNA expression of many other genes, with 3,426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF1-associated genes across cancer lineages are CUL2, CD207, and MRPS15. Each is linked with MARCHF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MARCHF1-to-partner and partner-to-MARCHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUL2 grouped by MARCHF1-low versus MARCHF1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF1→partner) and Y-score (partner→MARCHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CUL2 →	+0.468	+2.272	<.001	<.001	3	3
LUAD	CD207 →	-1.472	-2.584	<.001	<.001	3	3
UCEC	MRPS15 →	+0.426	+3.129	<.001	<.001	3	3
UCEC	EXOSC9 →	+0.365	+2.346	.003	.003	3	3
UCEC	KNL1 →	+0.605	+2.949	<.001	<.001	3	3
LUAD	FANCI →	+0.768	+2.201	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,426 associations by consensus.

CUL2 by MARCHF1 expression — LUAD

Explore this box plot interactively →