MARCHF1

Across TCGA patient cohorts, MARCHF1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF1-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and eEF2. Each is linked with MARCHF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MARCHF1-to-partner and partner-to-MARCHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MARCHF1-low versus MARCHF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF1→partner) and Y-score (partner→MARCHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.199	+2.263	.004	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.771	+1.434	<.001	.027	3	3
SKCM	eEF2 →	+0.271	+1.700	.032	.040	3	2
LUAD	FoxM1 →	+0.340	+2.492	<.001	.009	3	2
LUAD	MIG-6 →	+0.259	+2.087	<.001	.005	3	2
LUAD	PDCD4 →	-0.431	-3.459	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

eIF4E by MARCHF1 expression — UCEC

Explore this box plot interactively →