MARCHF1

Across TCGA cell cohorts, MARCHF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,859 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MARCHF1-associated GO terms across cancer lineages are Protein modification by small protein removal, mRNA destabilization, and Protein deubiquitination. Each is linked with MARCHF1 in more than 13 cancer types. Because this analysis shows association rather than direction, both MARCHF1-to-partner and partner-to-MARCHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein modification by small protein removal grouped by MARCHF1-low versus MARCHF1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF1→partner) and Y-score (partner→MARCHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein modification by small protein removal →	+0.047	+0.992	<.001	<.001	3	14
BLOOD_Leukemia	mRNA destabilization →	+0.035	+0.596	<.001	<.001	3	14
BLOOD_Myeloma	Protein deubiquitination →	+0.053	+0.511	.001	.007	3	13
BREAST	Nucleic acid catabolic process →	+0.046	+0.726	<.001	<.001	3	13
OESOPHAGUS	mRNA splice site recognition →	+0.153	+1.160	<.001	.004	3	13
BLOOD_Leukemia	Positive regulation of mRNA metabolic process →	+0.049	+0.989	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,859 associations by consensus.

Protein modification by small protein removal by MARCHF1 expression — LUNG_SCLC

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