MARCHF1

Across TCGA cell cohorts, MARCHF1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARCHF1-associated genes across cancer lineages are IL26, ECE2, and OR10W1. Each is linked with MARCHF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF1-to-partner and partner-to-MARCHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL26 grouped by MARCHF1-low versus MARCHF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF1→partner) and Y-score (partner→MARCHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IL26 →	+0.523	+3.793	<.001	.007	3	1
LARGE_INTESTINE	ECE2 →	+0.360	+4.054	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	LRRC3C →	+0.404	+3.777	<.001	.007	3	1
LARGE_INTESTINE	IQCF6 →	+0.296	+4.882	<.001	<.001	3	1
LARGE_INTESTINE	TP53TG3E →	+0.012	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IL26 by MARCHF1 expression — LARGE_INTESTINE

Explore this box plot interactively →